The native range of this species is S. Mexico to Tropical America. It is an epiphyte or lithophyte and grows primarily in the wet tropical biome.

The plant is propogared with stem cuttings. Peperomia scandens is favored for its ease of care, attractive foliage, and adaptability to indoor conditions. Its vining nature makes it a versatile choice for adding a touch of greenery.

The plant possesses cordate, leathery, fleshy leaves, possess glossy and waxy appearance; cultivars also available with variegated leaves.